Chemical Research of Freebase Freebase (also – free base) is an amine pure basic form - in contrast to its salt form – which is an alkaloid natural product. As a rule, freebase is used in pharmaceuticals to differentiate the un-protonated amine form in a compound. Here is what the chemical research has to convey about the formation of freebase. Majority of alkaloids in pure forms are unstable and are often accumulated as salts. And the latter as a rule are characterized by better solubility in water. Among most common counter-ions (salts) are: bromide, chloride, oxalate and acetate. The reaction of hydrochloric acid with amine, chloride salt, is formed with its other amine derivatives, classified as hydrochlorides.

And here is the chemical research for the freebase formation in drug industry. In order to prepare freebase out of cocaine sold in the streets, the latter undergoes the process of de-protonation of its hydrochloride salt. During this process also removed are inactive impurities. Chemical research gives the following explanation, why freebase is preferred for smoking: the time span between the desertion point and burning point of freebase is longer, and the salt form is more apt to destruction by pyrolysis. Freebase gained popularity in the U.S. in the 1980’s due to the impending danger of HIV and other diseases communicated by sharing injection needles.